Epithelial-mesenchymal transition and pancreatic cancer progression
نویسندگان
چکیده
Pancreatic ductal adenocarcinoma (PDAC) continues to be one of the most lethal human malignancies, with median survival of less than one year and overall 5-year survival of less than 5%. There is increasing evidence for contribution of epithelialmesenchymal transition (EMT) to pancreatic cancer metastasis and to treatment resistance. In this chapter we will review the role of EMT in pancreatic cancer progression, focusing particularly on the transcription factors and microRNAs involved in EMT. We will examine how EMT is involved in the generation and maintenance of stem cells, and detail the role of EMT in modulating resistance of PDAC cells to drug therapies. Finally, we will identify putative EMT-targeting agents that may help to reduce the morbidity and mortality associated with pancreatic cancer. Correspondence/Reprint request: Dr. Surabhi Dangi-Garimella, Hidayatullah G. Munshi, Division of Hematology/Oncology, Department of Medicine, Chicago, IL 60611, USA E-mails: [email protected] or [email protected] Surabhi Dangi-Garimella et al. 96
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